منابع مشابه
Obliterative small airway diseases in rheumatoid arthritis.
disease involving manyorgan systems. Amongthem, respiratory involvement is frequent including pleuritis, interstitial pneumonitis/flbrosis, and bronchiolitis; the latter two can be life threatening. Obliterative bronchiolopathies in the general population are classified into 3 categories : bronchiolitis obliterans (BO ; obliterative bronchiolitis, OB), diffuse panbronchiolitis (DPB) and bronchi...
متن کاملAirway remodeling and RELM-
TYPE 2 INFLAMMATORY RESPONSES are characterized by differentiated CD4 T helper type 2 (Th2) cells that secrete a panel of cytokines including IL-4, IL-5, IL-9, and IL-13 with the recruitment of multiple effector cells, including B cells producing IgE, mast cells, eosinophils, and basophils. Although inflammation per se attracts a great deal of attention, it is the effects of inflammation on tis...
متن کاملIntegrity of airway epithelium is essential against obliterative airway disease in transplanted rat tracheas.
BACKGROUND The pathogenesis of obliterative bronchiolitis after lung transplantation requires further elucidation. In this study we used rat trachea transplantation to examine the role of epithelium in the progression of obliterative airway disease. METHODS Normal and denuded (i.e., epithelium removed) trachea grafts from Lewis (LEW) and Brown Norway (BN) rats were transplanted sub-cutaneousl...
متن کاملChlamydia pneumoniae and airway remodeling.
To the Editor: I would like to comment on the interesting study by Pasternack et al, 1 who reported on relationships among Chlamydia pneumoniae antibodies, asthma incidence, and lung function in a 15-year prospective, population-based, adult cohort using a nested case-control methodology of 83 cases and 162 controls selected from a total population of 8000 subjects. For nonatopic asthma, they f...
متن کاملPATHOGENESIS OF COPD Airway Remodeling
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease associated with progressive airflow obstruction. Tobacco smoking is the main risk factor worldwide. In contrast to asthma, antiinflammatory therapies are rather ineffective in improving chronic symptoms and reducing inflammation, lung function decline, and airway remodeling. Specific drugs that are directed agai...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2011
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2010.10.032